Natural vaginal discharge fluid

Широбоков National Medical University named after o. Bogomolets Ukraine. In recent decades increased interest in natural microbiome - microbial communities colonizing the mucous membranes and skin of human. Microbiome is involved in metabolic and genetic regulatory mechanisms of human life, and also creates a powerful defense of microorganism from colonizing alien microorganisms. Mouth, upper respiratory tract, gastrointestinal and urogenital tract, skin are populated by different types of microorganisms. It was found that the breach of the vaginal microbiome associated with the development of bacterial vaginosis, nonspecific aerobic , vaginitis and mycotic vaginitis.

Meath, Ireland. Cervico-vaginal mucus CVM , the product of epithelial cells lining the uterus, cervix and vagina, is secreted to facilitate uterine lubrication and microbial clearance. Predominantly composed of water and mucins, CVM also contains high levels of immuno-active proteins such as immunoglobulin A IgA , lactoferrin and lysozyme which protect against infection by blocking adhesion and mediating microbial killing. The repertoire of cytokines, chemokines and antimicrobial peptides is predominantly generated by the secretions of endometrial epithelial cells into the uterine lumen and concentrated in the CVM. The quantity and relative proportions of these inflammatory biomarkers are affected by diverse factors including the estrus cycle and health status of the animal and therefore potentially provide important diagnostic and prognostic indicators.

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